Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
Identifieur interne : 006755 ( Main/Exploration ); précédent : 006754; suivant : 006756Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labeling
Auteurs : Philip V'Kovski [Suisse] ; Markus Gerber [Suisse] ; Jenna Kelly [Suisse] ; Stephanie Pfaender [Suisse] ; Nadine Ebert [Suisse] ; Sophie Braga Lagache [Suisse] ; Cedric Simillion [Suisse] ; Jasmine Portmann [Suisse] ; Hanspeter Stalder [Suisse] ; Véronique Gaschen [Suisse] ; Rémy Bruggmann [Suisse] ; Michael H. Stoffel [Suisse] ; Manfred Heller [Suisse] ; Ronald Dijkman [Suisse] ; Volker Thiel [Suisse]Source :
- eLife [ 2050-084X ] ; ????.
Abstract
Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase into a coronaviral replication/transcription complex (RTC) and identified >500 host proteins constituting the RTC microenvironment. siRNA-silencing of each RTC-proximal host factor demonstrated importance of vesicular trafficking pathways, ubiquitin-dependent and autophagy-related processes, and translation initiation factors. Notably, detection of translation initiation factors at the RTC was instrumental to visualize and demonstrate active translation proximal to replication complexes of several coronaviruses. Collectively, we establish a spatial link between viral RNA synthesis and diverse host factors of unprecedented breadth. Our data may serve as a paradigm for other positive-strand RNA viruses and provide a starting point for a comprehensive analysis of critical virus-host interactions that represent targets for therapeutic intervention.
Url:
DOI: 10.7554/eLife.42037
PubMed: 30632963
PubMed Central: 6372286
Affiliations:
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last="V'Kovski">Philip V'Kovski</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="dept">Graduate School for Biomedical Science</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gerber, Markus" sort="Gerber, Markus" uniqKey="Gerber M" first="Markus" last="Gerber">Markus Gerber</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kelly, Jenna" sort="Kelly, Jenna" uniqKey="Kelly J" first="Jenna" last="Kelly">Jenna Kelly</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Interfaculty Bioinformatics Unit, SIB Swiss Institute of Bioinformatics</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pfaender, Stephanie" sort="Pfaender, Stephanie" uniqKey="Pfaender S" first="Stephanie" last="Pfaender">Stephanie Pfaender</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ebert, Nadine" sort="Ebert, Nadine" uniqKey="Ebert N" first="Nadine" last="Ebert">Nadine Ebert</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Braga Lagache, Sophie" sort="Braga Lagache, Sophie" uniqKey="Braga Lagache S" first="Sophie" last="Braga Lagache">Sophie Braga Lagache</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Mass Spectrometry and Proteomics Core Facility, Department for BioMedical Research (DBMR)</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simillion, Cedric" sort="Simillion, Cedric" uniqKey="Simillion C" first="Cedric" last="Simillion">Cedric Simillion</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Mass Spectrometry and Proteomics Core Facility, Department for BioMedical Research (DBMR)</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="dept">Department of Clinical Research</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Portmann, Jasmine" sort="Portmann, Jasmine" uniqKey="Portmann J" first="Jasmine" last="Portmann">Jasmine Portmann</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stalder, Hanspeter" sort="Stalder, Hanspeter" uniqKey="Stalder H" first="Hanspeter" last="Stalder">Hanspeter Stalder</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gaschen, Veronique" sort="Gaschen, Veronique" uniqKey="Gaschen V" first="Véronique" last="Gaschen">Véronique Gaschen</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="dept">Division of Veterinary Anatomy, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bruggmann, Remy" sort="Bruggmann, Remy" uniqKey="Bruggmann R" first="Rémy" last="Bruggmann">Rémy Bruggmann</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution content-type="dept">Interfaculty Bioinformatics Unit, SIB Swiss Institute of Bioinformatics</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoffel, Michael H" sort="Stoffel, Michael H" uniqKey="Stoffel M" first="Michael H" last="Stoffel">Michael H. Stoffel</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution content-type="dept">Division of Veterinary Anatomy, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Heller, Manfred" sort="Heller, Manfred" uniqKey="Heller M" first="Manfred" last="Heller">Manfred Heller</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="dept">Mass Spectrometry and Proteomics Core Facility, Department for BioMedical Research (DBMR)</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dijkman, Ronald" sort="Dijkman, Ronald" uniqKey="Dijkman R" first="Ronald" last="Dijkman">Ronald Dijkman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute of Virology and Immunology IVI</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="dept">Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty</institution><institution>University of Bern</institution><addr-line>Bern</addr-line><country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Positive-sense RNA viruses hijack intracellular membranes that provide niches for viral RNA synthesis and a platform for interactions with host proteins. However, little is known about host factors at the interface between replicase complexes and the host cytoplasm. We engineered a biotin ligase into a coronaviral replication/transcription complex (RTC) and identified >500 host proteins constituting the RTC microenvironment. siRNA-silencing of each RTC-proximal host factor demonstrated importance of vesicular trafficking pathways, ubiquitin-dependent and autophagy-related processes, and translation initiation factors. Notably, detection of translation initiation factors at the RTC was instrumental to visualize and demonstrate active translation proximal to replication complexes of several coronaviruses. Collectively, we establish a spatial link between viral RNA synthesis and diverse host factors of unprecedented breadth. Our data may serve as a paradigm for other positive-strand RNA viruses and provide a starting point for a comprehensive analysis of critical virus-host interactions that represent targets for therapeutic intervention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ashburner, M" uniqKey="Ashburner M">M Ashburner</name></author><author><name sortKey="Ball, Ca" uniqKey="Ball C">CA Ball</name></author><author><name sortKey="Blake, Ja" uniqKey="Blake J">JA Blake</name></author><author><name sortKey="Botstein, D" uniqKey="Botstein D">D Botstein</name></author><author><name sortKey="Butler, H" uniqKey="Butler H">H Butler</name></author><author><name sortKey="Cherry, Jm" uniqKey="Cherry J">JM Cherry</name></author><author><name sortKey="Davis, Ap" uniqKey="Davis A">AP Davis</name></author><author><name sortKey="Dolinski, K" uniqKey="Dolinski K">K Dolinski</name></author><author><name sortKey="Dwight, Ss" uniqKey="Dwight S">SS Dwight</name></author><author><name sortKey="Eppig, Jt" uniqKey="Eppig J">JT Eppig</name></author><author><name sortKey="Harris, Ma" uniqKey="Harris M">MA Harris</name></author><author><name sortKey="Hill, Dp" uniqKey="Hill D">DP Hill</name></author><author><name sortKey="Issel Tarver, L" uniqKey="Issel Tarver L">L Issel-Tarver</name></author><author><name sortKey="Kasarskis, A" uniqKey="Kasarskis A">A Kasarskis</name></author><author><name sortKey="Lewis, S" uniqKey="Lewis S">S Lewis</name></author><author><name sortKey="Matese, Jc" uniqKey="Matese J">JC Matese</name></author><author><name sortKey="Richardson, Je" uniqKey="Richardson J">JE Richardson</name></author><author><name sortKey="Ringwald, M" uniqKey="Ringwald M">M Ringwald</name></author><author><name sortKey="Rubin, Gm" uniqKey="Rubin G">GM Rubin</name></author><author><name sortKey="Sherlock, G" uniqKey="Sherlock G">G Sherlock</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Athmer, J" uniqKey="Athmer J">J Athmer</name></author><author><name sortKey="Fehr, Ar" uniqKey="Fehr A">AR Fehr</name></author><author><name sortKey="Grunewald, M" uniqKey="Grunewald M">M Grunewald</name></author><author><name sortKey="Smith, Ec" uniqKey="Smith E">EC Smith</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bailey Elkin, Ba" uniqKey="Bailey Elkin B">BA Bailey-Elkin</name></author><author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name></author><author><name sortKey="Johnson, Gg" uniqKey="Johnson G">GG Johnson</name></author><author><name sortKey="Dalebout, Tj" uniqKey="Dalebout T">TJ Dalebout</name></author><author><name sortKey="Ninaber, Dk" uniqKey="Ninaber D">DK Ninaber</name></author><author><name sortKey="Van Kasteren, Pb" uniqKey="Van Kasteren P">PB van Kasteren</name></author><author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author><author><name sortKey="Mark, Bl" uniqKey="Mark B">BL Mark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barretto, N" uniqKey="Barretto N">N Barretto</name></author><author><name sortKey="Jukneliene, D" uniqKey="Jukneliene D">D Jukneliene</name></author><author><name sortKey="Ratia, K" uniqKey="Ratia K">K Ratia</name></author><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z Chen</name></author><author><name sortKey="Mesecar, Ad" uniqKey="Mesecar A">AD Mesecar</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bermingham, A" uniqKey="Bermingham A">A Bermingham</name></author><author><name sortKey="Chand, Ma" uniqKey="Chand M">MA Chand</name></author><author><name sortKey="Brown, Cs" uniqKey="Brown C">CS Brown</name></author><author><name sortKey="Aarons, E" uniqKey="Aarons E">E Aarons</name></author><author><name sortKey="Tong, C" uniqKey="Tong C">C Tong</name></author><author><name sortKey="Langrish, C" uniqKey="Langrish C">C Langrish</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name></author><author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R Myers</name></author><author><name sortKey="Pebody, Rg" uniqKey="Pebody R">RG Pebody</name></author><author><name sortKey="Green, Hk" uniqKey="Green H">HK Green</name></author><author><name sortKey="Boddington, Nl" uniqKey="Boddington N">NL Boddington</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name></author><author><name sortKey="Price, N" uniqKey="Price N">N Price</name></author><author><name sortKey="Newsholme, W" uniqKey="Newsholme W">W Newsholme</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bost, Ag" uniqKey="Bost A">AG Bost</name></author><author><name sortKey="Prentice, E" uniqKey="Prentice E">E Prentice</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braga Lagache, S" uniqKey="Braga Lagache S">S Braga-Lagache</name></author><author><name sortKey="Buchs, N" uniqKey="Buchs N">N Buchs</name></author><author><name sortKey="Iacovache, Mi" uniqKey="Iacovache M">MI Iacovache</name></author><author><name sortKey="Zuber, B" uniqKey="Zuber B">B Zuber</name></author><author><name sortKey="Jackson, Cb" uniqKey="Jackson C">CB Jackson</name></author><author><name sortKey="Heller, M" uniqKey="Heller M">M Heller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbon, S" uniqKey="Carbon S">S Carbon</name></author><author><name sortKey="Ireland, A" uniqKey="Ireland A">A Ireland</name></author><author><name sortKey="Mungall, Cj" uniqKey="Mungall C">CJ Mungall</name></author><author><name sortKey="Shu, S" uniqKey="Shu S">S Shu</name></author><author><name sortKey="Marshall, B" uniqKey="Marshall B">B Marshall</name></author><author><name sortKey="Lewis, S" uniqKey="Lewis S">S Lewis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coley, Se" uniqKey="Coley S">SE Coley</name></author><author><name sortKey="Lavi, E" uniqKey="Lavi E">E Lavi</name></author><author><name sortKey="Sawicki, Sg" uniqKey="Sawicki S">SG Sawicki</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B Schelle</name></author><author><name sortKey="Karl, N" uniqKey="Karl N">N Karl</name></author><author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cortese, M" uniqKey="Cortese M">M Cortese</name></author><author><name sortKey="Goellner, S" uniqKey="Goellner S">S Goellner</name></author><author><name sortKey="Acosta, Eg" uniqKey="Acosta E">EG Acosta</name></author><author><name sortKey="Neufeldt, Cj" uniqKey="Neufeldt C">CJ Neufeldt</name></author><author><name sortKey="Oleksiuk, O" uniqKey="Oleksiuk O">O Oleksiuk</name></author><author><name sortKey="Lampe, M" uniqKey="Lampe M">M Lampe</name></author><author><name sortKey="Haselmann, U" uniqKey="Haselmann U">U Haselmann</name></author><author><name sortKey="Funaya, C" uniqKey="Funaya C">C Funaya</name></author><author><name sortKey="Schieber, N" uniqKey="Schieber N">N Schieber</name></author><author><name sortKey="Ronchi, P" uniqKey="Ronchi P">P Ronchi</name></author><author><name sortKey="Schorb, M" uniqKey="Schorb M">M Schorb</name></author><author><name sortKey="Pruunsild, P" uniqKey="Pruunsild P">P Pruunsild</name></author><author><name sortKey="Schwab, Y" uniqKey="Schwab Y">Y Schwab</name></author><author><name sortKey="Chatel Chaix, L" uniqKey="Chatel Chaix L">L Chatel-Chaix</name></author><author><name sortKey="Ruggieri, A" uniqKey="Ruggieri A">A Ruggieri</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Croft, D" uniqKey="Croft D">D Croft</name></author><author><name sortKey="Mundo, Af" uniqKey="Mundo A">AF Mundo</name></author><author><name sortKey="Haw, R" uniqKey="Haw R">R Haw</name></author><author><name sortKey="Milacic, M" uniqKey="Milacic M">M Milacic</name></author><author><name sortKey="Weiser, J" uniqKey="Weiser J">J Weiser</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G Wu</name></author><author><name sortKey="Caudy, M" uniqKey="Caudy M">M Caudy</name></author><author><name sortKey="Garapati, P" uniqKey="Garapati P">P Garapati</name></author><author><name sortKey="Gillespie, M" uniqKey="Gillespie M">M Gillespie</name></author><author><name sortKey="Kamdar, Mr" uniqKey="Kamdar M">MR Kamdar</name></author><author><name sortKey="Jassal, B" uniqKey="Jassal B">B Jassal</name></author><author><name sortKey="Jupe, S" uniqKey="Jupe S">S Jupe</name></author><author><name sortKey="Matthews, L" uniqKey="Matthews L">L Matthews</name></author><author><name sortKey="May, B" uniqKey="May B">B May</name></author><author><name sortKey="Palatnik, S" uniqKey="Palatnik S">S Palatnik</name></author><author><name sortKey="Rothfels, K" uniqKey="Rothfels K">K Rothfels</name></author><author><name sortKey="Shamovsky, V" uniqKey="Shamovsky V">V Shamovsky</name></author><author><name sortKey="Song, H" uniqKey="Song H">H Song</name></author><author><name sortKey="Williams, M" uniqKey="Williams M">M Williams</name></author><author><name sortKey="Birney, E" uniqKey="Birney E">E Birney</name></author><author><name sortKey="Hermjakob, H" uniqKey="Hermjakob H">H Hermjakob</name></author><author><name sortKey="Stein, L" uniqKey="Stein L">L Stein</name></author><author><name sortKey="D Eustachio, P" uniqKey="D Eustachio P">P D'Eustachio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="David, A" uniqKey="David A">A David</name></author><author><name sortKey="Dolan, Bp" uniqKey="Dolan B">BP Dolan</name></author><author><name sortKey="Hickman, Hd" uniqKey="Hickman H">HD Hickman</name></author><author><name sortKey="Knowlton, Jj" uniqKey="Knowlton J">JJ Knowlton</name></author><author><name sortKey="Clavarino, G" uniqKey="Clavarino G">G Clavarino</name></author><author><name sortKey="Pierre, P" uniqKey="Pierre P">P Pierre</name></author><author><name sortKey="Bennink, Jr" uniqKey="Bennink J">JR Bennink</name></author><author><name sortKey="Yewdell, Jw" uniqKey="Yewdell J">JW Yewdell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Van Der Most, Rg" uniqKey="Van Der Most R">RG van der Most</name></author><author><name sortKey="Spaan, Wj" uniqKey="Spaan W">WJ Spaan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH de Wilde</name></author><author><name sortKey="Wannee, Kf" uniqKey="Wannee K">KF Wannee</name></author><author><name sortKey="Scholte, Fe" uniqKey="Scholte F">FE Scholte</name></author><author><name sortKey="Goeman, Jj" uniqKey="Goeman J">JJ Goeman</name></author><author><name sortKey="Ten Dijke, P" uniqKey="Ten Dijke P">P Ten Dijke</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author><author><name sortKey="Van Hemert, Mj" uniqKey="Van Hemert M">MJ van Hemert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decroly, E" uniqKey="Decroly E">E Decroly</name></author><author><name sortKey="Imbert, I" uniqKey="Imbert I">I Imbert</name></author><author><name sortKey="Coutard, B" uniqKey="Coutard B">B Coutard</name></author><author><name sortKey="Bouvet, M" uniqKey="Bouvet M">M Bouvet</name></author><author><name sortKey="Selisko, B" uniqKey="Selisko B">B Selisko</name></author><author><name sortKey="Alvarez, K" uniqKey="Alvarez K">K Alvarez</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Canard, B" uniqKey="Canard B">B Canard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deng, X" uniqKey="Deng X">X Deng</name></author><author><name sortKey="Hackbart, M" uniqKey="Hackbart M">M Hackbart</name></author><author><name sortKey="Mettelman, Rc" uniqKey="Mettelman R">RC Mettelman</name></author><author><name sortKey="O Brien, A" uniqKey="O Brien A">A O'Brien</name></author><author><name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name></author><author><name sortKey="Yi, G" uniqKey="Yi G">G Yi</name></author><author><name sortKey="Kao, Cc" uniqKey="Kao C">CC Kao</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Zoltick, Pw" uniqKey="Zoltick P">PW Zoltick</name></author><author><name sortKey="Hughes, Sa" uniqKey="Hughes S">SA Hughes</name></author><author><name sortKey="Giangreco, B" uniqKey="Giangreco B">B Giangreco</name></author><author><name sortKey="Olson, Al" uniqKey="Olson A">AL Olson</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Leibowitz, Jl" uniqKey="Leibowitz J">JL Leibowitz</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Spaan, Wj" uniqKey="Spaan W">WJ Spaan</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author><author><name sortKey="Gibson, Ca" uniqKey="Gibson C">CA Gibson</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Prentice, E" uniqKey="Prentice E">E Prentice</name></author><author><name sortKey="Lu, Xt" uniqKey="Lu X">XT Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desmet, Ea" uniqKey="Desmet E">EA Desmet</name></author><author><name sortKey="Anguish, Lj" uniqKey="Anguish L">LJ Anguish</name></author><author><name sortKey="Parker, Js" uniqKey="Parker J">JS Parker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, Ld" uniqKey="Eckerle L">LD Eckerle</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Sperry, Sm" uniqKey="Sperry S">SM Sperry</name></author><author><name sortKey="Choi, L" uniqKey="Choi L">L Choi</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eriksson, Kk" uniqKey="Eriksson K">KK Eriksson</name></author><author><name sortKey="Makia, D" uniqKey="Makia D">D Makia</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Mc" uniqKey="Freeman M">MC Freeman</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Peek, Ct" uniqKey="Peek C">CT Peek</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamerdinger, M" uniqKey="Gamerdinger M">M Gamerdinger</name></author><author><name sortKey="Hanebuth, Ma" uniqKey="Hanebuth M">MA Hanebuth</name></author><author><name sortKey="Frickey, T" uniqKey="Frickey T">T Frickey</name></author><author><name sortKey="Deuerling, E" uniqKey="Deuerling E">E Deuerling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gebhardt, A" uniqKey="Gebhardt A">A Gebhardt</name></author><author><name sortKey="Laudenbach, Bt" uniqKey="Laudenbach B">BT Laudenbach</name></author><author><name sortKey="Pichlmair, A" uniqKey="Pichlmair A">A Pichlmair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gosert, R" uniqKey="Gosert R">R Gosert</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Egger, D" uniqKey="Egger D">D Egger</name></author><author><name sortKey="Bienz, K" uniqKey="Bienz K">K Bienz</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Brockway, Sm" uniqKey="Brockway S">SM Brockway</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gunasekera, K" uniqKey="Gunasekera K">K Gunasekera</name></author><author><name sortKey="Wuthrich, D" uniqKey="Wuthrich D">D Wüthrich</name></author><author><name sortKey="Braga Lagache, S" uniqKey="Braga Lagache S">S Braga-Lagache</name></author><author><name sortKey="Heller, M" uniqKey="Heller M">M Heller</name></author><author><name sortKey="Ochsenreiter, T" uniqKey="Ochsenreiter T">T Ochsenreiter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagemeijer, Mc" uniqKey="Hagemeijer M">MC Hagemeijer</name></author><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="Ulasli, M" uniqKey="Ulasli M">M Ulasli</name></author><author><name sortKey="Shaltiel, Ia" uniqKey="Shaltiel I">IA Shaltiël</name></author><author><name sortKey="De Vries, La" uniqKey="De Vries L">LA de Vries</name></author><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashem, Y" uniqKey="Hashem Y">Y Hashem</name></author><author><name sortKey="Des Georges, A" uniqKey="Des Georges A">A des Georges</name></author><author><name sortKey="Dhote, V" uniqKey="Dhote V">V Dhote</name></author><author><name sortKey="Langlois, R" uniqKey="Langlois R">R Langlois</name></author><author><name sortKey="Liao, Hy" uniqKey="Liao H">HY Liao</name></author><author><name sortKey="Grassucci, Ra" uniqKey="Grassucci R">RA Grassucci</name></author><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author><author><name sortKey="Frank, J" uniqKey="Frank J">J Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hornbeck, Pv" uniqKey="Hornbeck P">PV Hornbeck</name></author><author><name sortKey="Kornhauser, Jm" uniqKey="Kornhauser J">JM Kornhauser</name></author><author><name sortKey="Tkachev, S" uniqKey="Tkachev S">S Tkachev</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author><author><name sortKey="Skrzypek, E" uniqKey="Skrzypek E">E Skrzypek</name></author><author><name sortKey="Murray, B" uniqKey="Murray B">B Murray</name></author><author><name sortKey="Latham, V" uniqKey="Latham V">V Latham</name></author><author><name sortKey="Sullivan, M" uniqKey="Sullivan M">M Sullivan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Ny" uniqKey="Hsu N">NY Hsu</name></author><author><name sortKey="Ilnytska, O" uniqKey="Ilnytska O">O Ilnytska</name></author><author><name sortKey="Belov, G" uniqKey="Belov G">G Belov</name></author><author><name sortKey="Santiana, M" uniqKey="Santiana M">M Santiana</name></author><author><name sortKey="Chen, Yh" uniqKey="Chen Y">YH Chen</name></author><author><name sortKey="Takvorian, Pm" uniqKey="Takvorian P">PM Takvorian</name></author><author><name sortKey="Pau, C" uniqKey="Pau C">C Pau</name></author><author><name sortKey="Van Der Schaar, H" uniqKey="Van Der Schaar H">H van der Schaar</name></author><author><name sortKey="Kaushik Basu, N" uniqKey="Kaushik Basu N">N Kaushik-Basu</name></author><author><name sortKey="Balla, T" uniqKey="Balla T">T Balla</name></author><author><name sortKey="Cameron, Ce" uniqKey="Cameron C">CE Cameron</name></author><author><name sortKey="Ehrenfeld, E" uniqKey="Ehrenfeld E">E Ehrenfeld</name></author><author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name></author><author><name sortKey="Altan Bonnet, N" uniqKey="Altan Bonnet N">N Altan-Bonnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Daw" uniqKey="Huang D">daW Huang</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Daw" uniqKey="Huang D">daW Huang</name></author><author><name sortKey="Sherman, Bt" uniqKey="Sherman B">BT Sherman</name></author><author><name sortKey="Lempicki, Ra" uniqKey="Lempicki R">RA Lempicki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name></author><author><name sortKey="Rozovics, Jm" uniqKey="Rozovics J">JM Rozovics</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Semler, Bl" uniqKey="Semler B">BL Semler</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Rj" uniqKey="Jackson R">RJ Jackson</name></author><author><name sortKey="Hellen, Cu" uniqKey="Hellen C">CU Hellen</name></author><author><name sortKey="Pestova, Tv" uniqKey="Pestova T">TV Pestova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamitani, W" uniqKey="Kamitani W">W Kamitani</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Lokugamage, K" uniqKey="Lokugamage K">K Lokugamage</name></author><author><name sortKey="Ikegami, T" uniqKey="Ikegami T">T Ikegami</name></author><author><name sortKey="Ito, N" uniqKey="Ito N">N Ito</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author><author><name sortKey="Goto, S" uniqKey="Goto S">S Goto</name></author><author><name sortKey="Sato, Y" uniqKey="Sato Y">Y Sato</name></author><author><name sortKey="Kawashima, M" uniqKey="Kawashima M">M Kawashima</name></author><author><name sortKey="Furumichi, M" uniqKey="Furumichi M">M Furumichi</name></author><author><name sortKey="Tanabe, M" uniqKey="Tanabe M">M Tanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kelder, T" uniqKey="Kelder T">T Kelder</name></author><author><name sortKey="Van Iersel, Mp" uniqKey="Van Iersel M">MP van Iersel</name></author><author><name sortKey="Hanspers, K" uniqKey="Hanspers K">K Hanspers</name></author><author><name sortKey="Kutmon, M" uniqKey="Kutmon M">M Kutmon</name></author><author><name sortKey="Conklin, Br" uniqKey="Conklin B">BR Conklin</name></author><author><name sortKey="Evelo, Ct" uniqKey="Evelo C">CT Evelo</name></author><author><name sortKey="Pico, Ar" uniqKey="Pico A">AR Pico</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name></author><author><name sortKey="Gil Cruz, C" uniqKey="Gil Cruz C">C Gil-Cruz</name></author><author><name sortKey="Spanier, J" uniqKey="Spanier J">J Spanier</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wilhelm, J" uniqKey="Wilhelm J">J Wilhelm</name></author><author><name sortKey="Rabouw, Hh" uniqKey="Rabouw H">HH Rabouw</name></author><author><name sortKey="Zust, R" uniqKey="Zust R">R Züst</name></author><author><name sortKey="Hwang, M" uniqKey="Hwang M">M Hwang</name></author><author><name sortKey="V Kovski, P" uniqKey="V Kovski P">P V'kovski</name></author><author><name sortKey="Stalder, H" uniqKey="Stalder H">H Stalder</name></author><author><name sortKey="Marti, S" uniqKey="Marti S">S Marti</name></author><author><name sortKey="Habjan, M" uniqKey="Habjan M">M Habjan</name></author><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name></author><author><name sortKey="Elliot, R" uniqKey="Elliot R">R Elliot</name></author><author><name sortKey="Karl, N" uniqKey="Karl N">N Karl</name></author><author><name sortKey="Gaughan, C" uniqKey="Gaughan C">C Gaughan</name></author><author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name></author><author><name sortKey="Silverman, Rh" uniqKey="Silverman R">RH Silverman</name></author><author><name sortKey="Keller, M" uniqKey="Keller M">M Keller</name></author><author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B Ludewig</name></author><author><name sortKey="Bergmann, Cc" uniqKey="Bergmann C">CC Bergmann</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Kalinke, U" uniqKey="Kalinke U">U Kalinke</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoops, K" uniqKey="Knoops K">K Knoops</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author><author><name sortKey="Worm, Sh" uniqKey="Worm S">SH Worm</name></author><author><name sortKey="Zevenhoven Dobbe, Jc" uniqKey="Zevenhoven Dobbe J">JC Zevenhoven-Dobbe</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author><author><name sortKey="Koster, Aj" uniqKey="Koster A">AJ Koster</name></author><author><name sortKey="Mommaas, Am" uniqKey="Mommaas A">AM Mommaas</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knoops, K" uniqKey="Knoops K">K Knoops</name></author><author><name sortKey="Swett Tapia, C" uniqKey="Swett Tapia C">C Swett-Tapia</name></author><author><name sortKey="Van Den Worm, Sh" uniqKey="Van Den Worm S">SH van den Worm</name></author><author><name sortKey="Te Velthuis, Aj" uniqKey="Te Velthuis A">AJ Te Velthuis</name></author><author><name sortKey="Koster, Aj" uniqKey="Koster A">AJ Koster</name></author><author><name sortKey="Mommaas, Am" uniqKey="Mommaas A">AM Mommaas</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krummenacker, M" uniqKey="Krummenacker M">M Krummenacker</name></author><author><name sortKey="Paley, S" uniqKey="Paley S">S Paley</name></author><author><name sortKey="Mueller, L" uniqKey="Mueller L">L Mueller</name></author><author><name sortKey="Yan, T" uniqKey="Yan T">T Yan</name></author><author><name sortKey="Karp, Pd" uniqKey="Karp P">PD Karp</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, Ss" uniqKey="Lam S">SS Lam</name></author><author><name sortKey="Martell, Jd" uniqKey="Martell J">JD Martell</name></author><author><name sortKey="Kamer, Kj" uniqKey="Kamer K">KJ Kamer</name></author><author><name sortKey="Deerinck, Tj" uniqKey="Deerinck T">TJ Deerinck</name></author><author><name sortKey="Ellisman, Mh" uniqKey="Ellisman M">MH Ellisman</name></author><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author><author><name sortKey="Ting, Ay" uniqKey="Ting A">AY Ting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, As" uniqKey="Lee A">AS Lee</name></author><author><name sortKey="Burdeinick Kerr, R" uniqKey="Burdeinick Kerr R">R Burdeinick-Kerr</name></author><author><name sortKey="Whelan, Sp" uniqKey="Whelan S">SP Whelan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindner, Ha" uniqKey="Lindner H">HA Lindner</name></author><author><name sortKey="Fotouhi Ardakani, N" uniqKey="Fotouhi Ardakani N">N Fotouhi-Ardakani</name></author><author><name sortKey="Lytvyn, V" uniqKey="Lytvyn V">V Lytvyn</name></author><author><name sortKey="Lachance, P" uniqKey="Lachance P">P Lachance</name></author><author><name sortKey="Sulea, T" uniqKey="Sulea T">T Sulea</name></author><author><name sortKey="Menard, R" uniqKey="Menard R">R Ménard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Nakagawa, K" uniqKey="Nakagawa K">K Nakagawa</name></author><author><name sortKey="Terasaki, K" uniqKey="Terasaki K">K Terasaki</name></author><author><name sortKey="Ramirez, Si" uniqKey="Ramirez S">SI Ramirez</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundin, A" uniqKey="Lundin A">A Lundin</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Bergstrom, T" uniqKey="Bergstrom T">T Bergström</name></author><author><name sortKey="Kann, N" uniqKey="Kann N">N Kann</name></author><author><name sortKey="Adamiak, B" uniqKey="Adamiak B">B Adamiak</name></author><author><name sortKey="Hannoun, C" uniqKey="Hannoun C">C Hannoun</name></author><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name></author><author><name sortKey="J Nsd Ttir, Hr" uniqKey="J Nsd Ttir H">HR Jónsdóttir</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Kint, J" uniqKey="Kint J">J Kint</name></author><author><name sortKey="Forlenza, M" uniqKey="Forlenza M">M Forlenza</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Trybala, E" uniqKey="Trybala E">E Trybala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marceau, Cd" uniqKey="Marceau C">CD Marceau</name></author><author><name sortKey="Puschnik, As" uniqKey="Puschnik A">AS Puschnik</name></author><author><name sortKey="Majzoub, K" uniqKey="Majzoub K">K Majzoub</name></author><author><name sortKey="Ooi, Ys" uniqKey="Ooi Y">YS Ooi</name></author><author><name sortKey="Brewer, Sm" uniqKey="Brewer S">SM Brewer</name></author><author><name sortKey="Fuchs, G" uniqKey="Fuchs G">G Fuchs</name></author><author><name sortKey="Swaminathan, K" uniqKey="Swaminathan K">K Swaminathan</name></author><author><name sortKey="Mata, Ma" uniqKey="Mata M">MA Mata</name></author><author><name sortKey="Elias, Je" uniqKey="Elias J">JE Elias</name></author><author><name sortKey="Sarnow, P" uniqKey="Sarnow P">P Sarnow</name></author><author><name sortKey="Carette, Je" uniqKey="Carette J">JE Carette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martell, Jd" uniqKey="Martell J">JD Martell</name></author><author><name sortKey="Deerinck, Tj" uniqKey="Deerinck T">TJ Deerinck</name></author><author><name sortKey="Lam, Ss" uniqKey="Lam S">SS Lam</name></author><author><name sortKey="Ellisman, Mh" uniqKey="Ellisman M">MH Ellisman</name></author><author><name sortKey="Ting, Ay" uniqKey="Ting A">AY Ting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miorin, L" uniqKey="Miorin L">L Miorin</name></author><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name></author><author><name sortKey="Maiuri, P" uniqKey="Maiuri P">P Maiuri</name></author><author><name sortKey="Hoppe, S" uniqKey="Hoppe S">S Hoppe</name></author><author><name sortKey="Krijnse Locker, J" uniqKey="Krijnse Locker J">J Krijnse-Locker</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author><author><name sortKey="Marcello, A" uniqKey="Marcello A">A Marcello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monastyrska, I" uniqKey="Monastyrska I">I Monastyrska</name></author><author><name sortKey="Ulasli, M" uniqKey="Ulasli M">M Ulasli</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Guan, Jl" uniqKey="Guan J">JL Guan</name></author><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mutterer, J" uniqKey="Mutterer J">J Mutterer</name></author><author><name sortKey="Zinck, E" uniqKey="Zinck E">E Zinck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Ramirez, Si" uniqKey="Ramirez S">SI Ramirez</name></author><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neufeldt, Cj" uniqKey="Neufeldt C">CJ Neufeldt</name></author><author><name sortKey="Joyce, Ma" uniqKey="Joyce M">MA Joyce</name></author><author><name sortKey="Van Buuren, N" uniqKey="Van Buuren N">N Van Buuren</name></author><author><name sortKey="Levin, A" uniqKey="Levin A">A Levin</name></author><author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name></author><author><name sortKey="Gale, M" uniqKey="Gale M">M Gale</name></author><author><name sortKey="Tyrrell, Dl" uniqKey="Tyrrell D">DL Tyrrell</name></author><author><name sortKey="Wozniak, Rw" uniqKey="Wozniak R">RW Wozniak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novak, Je" uniqKey="Novak J">JE Novak</name></author><author><name sortKey="Kirkegaard, K" uniqKey="Kirkegaard K">K Kirkegaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oostra, M" uniqKey="Oostra M">M Oostra</name></author><author><name sortKey="Te Lintelo, Eg" uniqKey="Te Lintelo E">EG te Lintelo</name></author><author><name sortKey="Deijs, M" uniqKey="Deijs M">M Deijs</name></author><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oudshoorn, D" uniqKey="Oudshoorn D">D Oudshoorn</name></author><author><name sortKey="Rijs, K" uniqKey="Rijs K">K Rijs</name></author><author><name sortKey="Limpens, R" uniqKey="Limpens R">R Limpens</name></author><author><name sortKey="Groen, K" uniqKey="Groen K">K Groen</name></author><author><name sortKey="Koster, Aj" uniqKey="Koster A">AJ Koster</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author><author><name sortKey="Barcena, M" uniqKey="Barcena M">M Bárcena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Overby, Ak" uniqKey="Overby A">AK Overby</name></author><author><name sortKey="Popov, Vl" uniqKey="Popov V">VL Popov</name></author><author><name sortKey="Niedrig, M" uniqKey="Niedrig M">M Niedrig</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfefferle, S" uniqKey="Pfefferle S">S Pfefferle</name></author><author><name sortKey="Schopf, J" uniqKey="Schopf J">J Schöpf</name></author><author><name sortKey="Kogl, M" uniqKey="Kogl M">M Kögl</name></author><author><name sortKey="Friedel, Cc" uniqKey="Friedel C">CC Friedel</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Carbajo Lozoya, J" uniqKey="Carbajo Lozoya J">J Carbajo-Lozoya</name></author><author><name sortKey="Stellberger, T" uniqKey="Stellberger T">T Stellberger</name></author><author><name sortKey="Von Dall Armi, E" uniqKey="Von Dall Armi E">E von Dall'Armi</name></author><author><name sortKey="Herzog, P" uniqKey="Herzog P">P Herzog</name></author><author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name></author><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name></author><author><name sortKey="Ditt, V" uniqKey="Ditt V">V Ditt</name></author><author><name sortKey="Kuri, T" uniqKey="Kuri T">T Kuri</name></author><author><name sortKey="Zust, R" uniqKey="Zust R">R Züst</name></author><author><name sortKey="Pumpor, K" uniqKey="Pumpor K">K Pumpor</name></author><author><name sortKey="Hilgenfeld, R" uniqKey="Hilgenfeld R">R Hilgenfeld</name></author><author><name sortKey="Schwarz, F" uniqKey="Schwarz F">F Schwarz</name></author><author><name sortKey="Zimmer, R" uniqKey="Zimmer R">R Zimmer</name></author><author><name sortKey="Steffen, I" uniqKey="Steffen I">I Steffen</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Herrler, G" uniqKey="Herrler G">G Herrler</name></author><author><name sortKey="Thiel, Hj" uniqKey="Thiel H">HJ Thiel</name></author><author><name sortKey="Schwegmann Wessels, C" uniqKey="Schwegmann Wessels C">C Schwegmann-Wessels</name></author><author><name sortKey="Pohlmann, S" uniqKey="Pohlmann S">S Pöhlmann</name></author><author><name sortKey="Haas, J" uniqKey="Haas J">J Haas</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Von Brunn, A" uniqKey="Von Brunn A">A von Brunn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raaben, M" uniqKey="Raaben M">M Raaben</name></author><author><name sortKey="Groot Koerkamp, Mj" uniqKey="Groot Koerkamp M">MJ Groot Koerkamp</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raaben, M" uniqKey="Raaben M">M Raaben</name></author><author><name sortKey="Posthuma, Cc" uniqKey="Posthuma C">CC Posthuma</name></author><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="Te Lintelo, Eg" uniqKey="Te Lintelo E">EG te Lintelo</name></author><author><name sortKey="Kikkert, M" uniqKey="Kikkert M">M Kikkert</name></author><author><name sortKey="Drijfhout, Jw" uniqKey="Drijfhout J">JW Drijfhout</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raaben, M" uniqKey="Raaben M">M Raaben</name></author><author><name sortKey="Grinwis, Gc" uniqKey="Grinwis G">GC Grinwis</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Randall, G" uniqKey="Randall G">G Randall</name></author><author><name sortKey="Panis, M" uniqKey="Panis M">M Panis</name></author><author><name sortKey="Cooper, Jd" uniqKey="Cooper J">JD Cooper</name></author><author><name sortKey="Tellinghuisen, Tl" uniqKey="Tellinghuisen T">TL Tellinghuisen</name></author><author><name sortKey="Sukhodolets, Ke" uniqKey="Sukhodolets K">KE Sukhodolets</name></author><author><name sortKey="Pfeffer, S" uniqKey="Pfeffer S">S Pfeffer</name></author><author><name sortKey="Landthaler, M" uniqKey="Landthaler M">M Landthaler</name></author><author><name sortKey="Landgraf, P" uniqKey="Landgraf P">P Landgraf</name></author><author><name sortKey="Kan, S" uniqKey="Kan S">S Kan</name></author><author><name sortKey="Lindenbach, Bd" uniqKey="Lindenbach B">BD Lindenbach</name></author><author><name sortKey="Chien, M" uniqKey="Chien M">M Chien</name></author><author><name sortKey="Weir, Db" uniqKey="Weir D">DB Weir</name></author><author><name sortKey="Russo, Jj" uniqKey="Russo J">JJ Russo</name></author><author><name sortKey="Ju, J" uniqKey="Ju J">J Ju</name></author><author><name sortKey="Brownstein, Mj" uniqKey="Brownstein M">MJ Brownstein</name></author><author><name sortKey="Sheridan, R" uniqKey="Sheridan R">R Sheridan</name></author><author><name sortKey="Sander, C" uniqKey="Sander C">C Sander</name></author><author><name sortKey="Zavolan, M" uniqKey="Zavolan M">M Zavolan</name></author><author><name sortKey="Tuschl, T" uniqKey="Tuschl T">T Tuschl</name></author><author><name sortKey="Rice, Cm" uniqKey="Rice C">CM Rice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rapoport, Ta" uniqKey="Rapoport T">TA Rapoport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author><author><name sortKey="Monastyrska, I" uniqKey="Monastyrska I">I Monastyrska</name></author><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="Cali, T" uniqKey="Cali T">T Calì</name></author><author><name sortKey="Ulasli, M" uniqKey="Ulasli M">M Ulasli</name></author><author><name sortKey="Bianchi, S" uniqKey="Bianchi S">S Bianchi</name></author><author><name sortKey="Bernasconi, R" uniqKey="Bernasconi R">R Bernasconi</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Molinari, M" uniqKey="Molinari M">M Molinari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reid, Dw" uniqKey="Reid D">DW Reid</name></author><author><name sortKey="Campos, Rk" uniqKey="Campos R">RK Campos</name></author><author><name sortKey="Child, Jr" uniqKey="Child J">JR Child</name></author><author><name sortKey="Zheng, T" uniqKey="Zheng T">T Zheng</name></author><author><name sortKey="Chan, Kwk" uniqKey="Chan K">KWK Chan</name></author><author><name sortKey="Bradrick, Ss" uniqKey="Bradrick S">SS Bradrick</name></author><author><name sortKey="Vasudevan, Sg" uniqKey="Vasudevan S">SG Vasudevan</name></author><author><name sortKey="Garcia Blanco, Ma" uniqKey="Garcia Blanco M">MA Garcia-Blanco</name></author><author><name sortKey="Nicchitta, Cv" uniqKey="Nicchitta C">CV Nicchitta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name></author><author><name sortKey="Merz, A" uniqKey="Merz A">A Merz</name></author><author><name sortKey="Chiramel, A" uniqKey="Chiramel A">A Chiramel</name></author><author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name></author><author><name sortKey="Chlanda, P" uniqKey="Chlanda P">P Chlanda</name></author><author><name sortKey="Haselman, U" uniqKey="Haselman U">U Haselman</name></author><author><name sortKey="Santarella Mellwig, R" uniqKey="Santarella Mellwig R">R Santarella-Mellwig</name></author><author><name sortKey="Habermann, A" uniqKey="Habermann A">A Habermann</name></author><author><name sortKey="Hoppe, S" uniqKey="Hoppe S">S Hoppe</name></author><author><name sortKey="Kallis, S" uniqKey="Kallis S">S Kallis</name></author><author><name sortKey="Walther, P" uniqKey="Walther P">P Walther</name></author><author><name sortKey="Antony, C" uniqKey="Antony C">C Antony</name></author><author><name sortKey="Krijnse Locker, J" uniqKey="Krijnse Locker J">J Krijnse-Locker</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero Brey, I" uniqKey="Romero Brey I">I Romero-Brey</name></author><author><name sortKey="Bartenschlager, R" uniqKey="Bartenschlager R">R Bartenschlager</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, Kj" uniqKey="Roux K">KJ Roux</name></author><author><name sortKey="Kim, Di" uniqKey="Kim D">DI Kim</name></author><author><name sortKey="Raida, M" uniqKey="Raida M">M Raida</name></author><author><name sortKey="Burke, B" uniqKey="Burke B">B Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, Kj" uniqKey="Roux K">KJ Roux</name></author><author><name sortKey="Kim, Di" uniqKey="Kim D">DI Kim</name></author><author><name sortKey="Burke, B" uniqKey="Burke B">B Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sch Tz, G" uniqKey="Sch Tz G">G Schätz</name></author><author><name sortKey="Schneiter, M" uniqKey="Schneiter M">M Schneiter</name></author><author><name sortKey="Ri Ka, J" uniqKey="Ri Ka J">J Rička</name></author><author><name sortKey="Kuhni Boghenbor, K" uniqKey="Kuhni Boghenbor K">K Kühni-Boghenbor</name></author><author><name sortKey="Tschanz, Sa" uniqKey="Tschanz S">SA Tschanz</name></author><author><name sortKey="Doherr, Mg" uniqKey="Doherr M">MG Doherr</name></author><author><name sortKey="Frenz, M" uniqKey="Frenz M">M Frenz</name></author><author><name sortKey="Stoffel, Mh" uniqKey="Stoffel M">MH Stoffel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiller, Jj" uniqKey="Schiller J">JJ Schiller</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schweingruber, C" uniqKey="Schweingruber C">C Schweingruber</name></author><author><name sortKey="Rufener, Sc" uniqKey="Rufener S">SC Rufener</name></author><author><name sortKey="Zund, D" uniqKey="Zund D">D Zund</name></author><author><name sortKey="Yamashita, A" uniqKey="Yamashita A">A Yamashita</name></author><author><name sortKey="Muhlemann, O" uniqKey="Muhlemann O">O Mühlemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, M" uniqKey="Sharma M">M Sharma</name></author><author><name sortKey="Bhattacharyya, S" uniqKey="Bhattacharyya S">S Bhattacharyya</name></author><author><name sortKey="Nain, M" uniqKey="Nain M">M Nain</name></author><author><name sortKey="Kaur, M" uniqKey="Kaur M">M Kaur</name></author><author><name sortKey="Sood, V" uniqKey="Sood V">V Sood</name></author><author><name sortKey="Gupta, V" uniqKey="Gupta V">V Gupta</name></author><author><name sortKey="Khasa, R" uniqKey="Khasa R">R Khasa</name></author><author><name sortKey="Abdin, Mz" uniqKey="Abdin M">MZ Abdin</name></author><author><name sortKey="Vrati, S" uniqKey="Vrati S">S Vrati</name></author><author><name sortKey="Kalia, M" uniqKey="Kalia M">M Kalia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author><author><name sortKey="Ye, G" uniqKey="Ye G">G Ye</name></author><author><name sortKey="Deng, F" uniqKey="Deng F">F Deng</name></author><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name></author><author><name sortKey="Cui, M" uniqKey="Cui M">M Cui</name></author><author><name sortKey="Fang, L" uniqKey="Fang L">L Fang</name></author><author><name sortKey="Xiao, S" uniqKey="Xiao S">S Xiao</name></author><author><name sortKey="Fu, Zf" uniqKey="Fu Z">ZF Fu</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simillion, C" uniqKey="Simillion C">C Simillion</name></author><author><name sortKey="Liechti, R" uniqKey="Liechti R">R Liechti</name></author><author><name sortKey="Lischer, He" uniqKey="Lischer H">HE Lischer</name></author><author><name sortKey="Ioannidis, V" uniqKey="Ioannidis V">V Ioannidis</name></author><author><name sortKey="Bruggmann, R" uniqKey="Bruggmann R">R Bruggmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Ostermann, J" uniqKey="Ostermann J">J Ostermann</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Bredenbeek, Pj" uniqKey="Bredenbeek P">PJ Bredenbeek</name></author><author><name sortKey="Dobbe, Jc" uniqKey="Dobbe J">JC Dobbe</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Rozanov, M" uniqKey="Rozanov M">M Rozanov</name></author><author><name sortKey="Spaan, Wj" uniqKey="Spaan W">WJ Spaan</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soderberg, O" uniqKey="Soderberg O">O Söderberg</name></author><author><name sortKey="Gullberg, M" uniqKey="Gullberg M">M Gullberg</name></author><author><name sortKey="Jarvius, M" uniqKey="Jarvius M">M Jarvius</name></author><author><name sortKey="Ridderstr Le, K" uniqKey="Ridderstr Le K">K Ridderstråle</name></author><author><name sortKey="Leuchowius, Kj" uniqKey="Leuchowius K">KJ Leuchowius</name></author><author><name sortKey="Jarvius, J" uniqKey="Jarvius J">J Jarvius</name></author><author><name sortKey="Wester, K" uniqKey="Wester K">K Wester</name></author><author><name sortKey="Hydbring, P" uniqKey="Hydbring P">P Hydbring</name></author><author><name sortKey="Bahram, F" uniqKey="Bahram F">F Bahram</name></author><author><name sortKey="Larsson, Lg" uniqKey="Larsson L">LG Larsson</name></author><author><name sortKey="Landegren, U" uniqKey="Landegren U">U Landegren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szklarczyk, D" uniqKey="Szklarczyk D">D Szklarczyk</name></author><author><name sortKey="Franceschini, A" uniqKey="Franceschini A">A Franceschini</name></author><author><name sortKey="Wyder, S" uniqKey="Wyder S">S Wyder</name></author><author><name sortKey="Forslund, K" uniqKey="Forslund K">K Forslund</name></author><author><name sortKey="Heller, D" uniqKey="Heller D">D Heller</name></author><author><name sortKey="Huerta Cepas, J" uniqKey="Huerta Cepas J">J Huerta-Cepas</name></author><author><name sortKey="Simonovic, M" uniqKey="Simonovic M">M Simonovic</name></author><author><name sortKey="Roth, A" uniqKey="Roth A">A Roth</name></author><author><name sortKey="Santos, A" uniqKey="Santos A">A Santos</name></author><author><name sortKey="Tsafou, Kp" uniqKey="Tsafou K">KP Tsafou</name></author><author><name sortKey="Kuhn, M" uniqKey="Kuhn M">M Kuhn</name></author><author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name></author><author><name sortKey="Jensen, Lj" uniqKey="Jensen L">LJ Jensen</name></author><author><name sortKey="Von Mering, C" uniqKey="Von Mering C">C von Mering</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szklarczyk, D" uniqKey="Szklarczyk D">D Szklarczyk</name></author><author><name sortKey="Morris, Jh" uniqKey="Morris J">JH Morris</name></author><author><name sortKey="Cook, H" uniqKey="Cook H">H Cook</name></author><author><name sortKey="Kuhn, M" uniqKey="Kuhn M">M Kuhn</name></author><author><name sortKey="Wyder, S" uniqKey="Wyder S">S Wyder</name></author><author><name sortKey="Simonovic, M" uniqKey="Simonovic M">M Simonovic</name></author><author><name sortKey="Santos, A" uniqKey="Santos A">A Santos</name></author><author><name sortKey="Doncheva, Nt" uniqKey="Doncheva N">NT Doncheva</name></author><author><name sortKey="Roth, A" uniqKey="Roth A">A Roth</name></author><author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name></author><author><name sortKey="Jensen, Lj" uniqKey="Jensen L">LJ Jensen</name></author><author><name sortKey="Von Mering, C" uniqKey="Von Mering C">C von Mering</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Herold, J" uniqKey="Herold J">J Herold</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B Schelle</name></author><author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Ivanov, Ka" uniqKey="Ivanov K">KA Ivanov</name></author><author><name sortKey="Putics, A" uniqKey="Putics A">A Putics</name></author><author><name sortKey="Hertzig, T" uniqKey="Hertzig T">T Hertzig</name></author><author><name sortKey="Schelle, B" uniqKey="Schelle B">B Schelle</name></author><author><name sortKey="Bayer, S" uniqKey="Bayer S">S Bayer</name></author><author><name sortKey="Weissbrich, B" uniqKey="Weissbrich B">B Weissbrich</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H Rabenau</name></author><author><name sortKey="Doerr, Hw" uniqKey="Doerr H">HW Doerr</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ulasli, M" uniqKey="Ulasli M">M Ulasli</name></author><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Dobbe, Jc" uniqKey="Dobbe J">JC Dobbe</name></author><author><name sortKey="Schleich, S" uniqKey="Schleich S">S Schleich</name></author><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author><author><name sortKey="Spaan, Wj" uniqKey="Spaan W">WJ Spaan</name></author><author><name sortKey="Locker, Jk" uniqKey="Locker J">JK Locker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verheije, Mh" uniqKey="Verheije M">MH Verheije</name></author><author><name sortKey="Raaben, M" uniqKey="Raaben M">M Raaben</name></author><author><name sortKey="Mari, M" uniqKey="Mari M">M Mari</name></author><author><name sortKey="Te Lintelo, Eg" uniqKey="Te Lintelo E">EG Te Lintelo</name></author><author><name sortKey="Reggiori, F" uniqKey="Reggiori F">F Reggiori</name></author><author><name sortKey="Van Kuppeveld, Fj" uniqKey="Van Kuppeveld F">FJ van Kuppeveld</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de 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Nakagawa</name></author><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiedmann, B" uniqKey="Wiedmann B">B Wiedmann</name></author><author><name sortKey="Sakai, H" uniqKey="Sakai H">H Sakai</name></author><author><name sortKey="Davis, Ta" uniqKey="Davis T">TA Davis</name></author><author><name sortKey="Wiedmann, M" uniqKey="Wiedmann M">M Wiedmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Hh" uniqKey="Wong H">HH Wong</name></author><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author><author><name sortKey="Tay, Fp" uniqKey="Tay F">FP Tay</name></author><author><name sortKey="Moreau, D" uniqKey="Moreau D">D Moreau</name></author><author><name sortKey="Liu, Dx" uniqKey="Liu D">DX Liu</name></author><author><name sortKey="Bard, F" 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Gorman</name></author><author><name sortKey="Rausch, K" uniqKey="Rausch K">K Rausch</name></author><author><name sortKey="Ramage, H" uniqKey="Ramage H">H Ramage</name></author><author><name sortKey="White, Jp" uniqKey="White J">JP White</name></author><author><name sortKey="Zuiani, A" uniqKey="Zuiani A">A Zuiani</name></author><author><name sortKey="Zhang, P" uniqKey="Zhang P">P Zhang</name></author><author><name sortKey="Fernandez, E" uniqKey="Fernandez E">E Fernandez</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author><author><name sortKey="Dowd, Ka" uniqKey="Dowd K">KA Dowd</name></author><author><name sortKey="Pierson, Tc" uniqKey="Pierson T">TC Pierson</name></author><author><name sortKey="Cherry, S" uniqKey="Cherry S">S Cherry</name></author><author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, G" uniqKey="Zheng G">G Zheng</name></author><author><name sortKey="Tu, K" uniqKey="Tu K">K Tu</name></author><author><name sortKey="Yang, Q" uniqKey="Yang Q">Q Yang</name></author><author><name sortKey="Xiong, Y" uniqKey="Xiong Y">Y Xiong</name></author><author><name sortKey="Wei, C" uniqKey="Wei C">C Wei</name></author><author><name sortKey="Xie, L" uniqKey="Xie L">L Xie</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zust, R" uniqKey="Zust R">R Züst</name></author><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragán</name></author><author><name sortKey="Kuri, T" uniqKey="Kuri T">T Kuri</name></author><author><name sortKey="Blakqori, G" uniqKey="Blakqori G">G Blakqori</name></author><author><name sortKey="Weber, F" uniqKey="Weber F">F Weber</name></author><author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B Ludewig</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zust, R" uniqKey="Zust R">R Züst</name></author><author><name sortKey="Cervantes Barragan, L" uniqKey="Cervantes Barragan L">L Cervantes-Barragan</name></author><author><name sortKey="Habjan, M" uniqKey="Habjan M">M Habjan</name></author><author><name sortKey="Maier, R" uniqKey="Maier R">R Maier</name></author><author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Szretter, Kj" uniqKey="Szretter K">KJ Szretter</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name></author><author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name></author><author><name 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last="Kelly">Jenna Kelly</name><name sortKey="Kelly, Jenna" sort="Kelly, Jenna" uniqKey="Kelly J" first="Jenna" last="Kelly">Jenna Kelly</name><name sortKey="Pfaender, Stephanie" sort="Pfaender, Stephanie" uniqKey="Pfaender S" first="Stephanie" last="Pfaender">Stephanie Pfaender</name><name sortKey="Pfaender, Stephanie" sort="Pfaender, Stephanie" uniqKey="Pfaender S" first="Stephanie" last="Pfaender">Stephanie Pfaender</name><name sortKey="Portmann, Jasmine" sort="Portmann, Jasmine" uniqKey="Portmann J" first="Jasmine" last="Portmann">Jasmine Portmann</name><name sortKey="Portmann, Jasmine" sort="Portmann, Jasmine" uniqKey="Portmann J" first="Jasmine" last="Portmann">Jasmine Portmann</name><name sortKey="Simillion, Cedric" sort="Simillion, Cedric" uniqKey="Simillion C" first="Cedric" last="Simillion">Cedric Simillion</name><name sortKey="Simillion, Cedric" sort="Simillion, Cedric" uniqKey="Simillion C" first="Cedric" last="Simillion">Cedric Simillion</name><name sortKey="Stalder, Hanspeter" sort="Stalder, Hanspeter" uniqKey="Stalder H" first="Hanspeter" last="Stalder">Hanspeter Stalder</name><name sortKey="Stalder, Hanspeter" sort="Stalder, Hanspeter" uniqKey="Stalder H" first="Hanspeter" last="Stalder">Hanspeter Stalder</name><name sortKey="Stoffel, Michael H" sort="Stoffel, Michael H" uniqKey="Stoffel M" first="Michael H" last="Stoffel">Michael H. Stoffel</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><name sortKey="V Kovski, Philip" sort="V Kovski, Philip" uniqKey="V Kovski P" first="Philip" last="V'Kovski">Philip V'Kovski</name><name sortKey="V Kovski, Philip" sort="V Kovski, Philip" uniqKey="V Kovski P" first="Philip" last="V'Kovski">Philip V'Kovski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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